Endovascular Microcoil Gene Delivery Using Immobilized Anti-adenovirus Antibody for Vector Tethering
نویسندگان
چکیده
منابع مشابه
Endovascular microcoil gene delivery using immobilized anti-adenovirus antibody for vector tethering.
BACKGROUND AND PURPOSE Endovascular microcoils are widely used in interventional procedures to treat cerebral aneurysms. In the present study we report for the first time successful use of an endovascular microcoil as a gene delivery system. METHODS Anti-adenoviral monoclonal antibodies were covalently attached to the collagen-coated surface of either platinum or polyglycolic acid microcoils....
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BACKGROUND Bleomycin (BLM) is an anticancer antibiotic used in many cancer regimens. Its utility is limited by systemic toxicity and dose-dependent pneumonitis able to progress to lung fibrosis. The latter can affect up to nearly 50% of the total patient population, out of which 3% will die. We propose to improve BLM delivery by tethering it to an efficient delivery vector. Adenovirus (Ad) dode...
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ژورنال
عنوان ژورنال: Stroke
سال: 2002
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000014327.03964.c0